Work

Cellular Potts modeling of complex multicellular behaviors in tissue morphogenesis

Year: 2017

Type: article

Abstract: Mathematical modeling is an essential approach for the understanding of complex multicellular behaviors in tissue morphogenesis. Here, we review the cellular Potts model (CPM; also known as the Glazier-Graner-Hogeweg model), an effective computational modeling framework. We discuss its usability for modeling complex developmental phenomena by examining four fundamental examples of tissue morphogenesis: (i) cell sorting, (ii) cyst formation, (iii) tube morphogenesis in kidney development, and (iv) blood vessel formation. The review provides an introduction for biologists for starting simulation analysis using the CPM framework.

Source: Development Growth & Differentiation

DOI: 10.1111/dgd.12358

Authors: Tsuyoshi Hirashima, Elisabeth G. Rens, Roeland M. H. Merks

Institutions: Kyoto University, Leiden University, Centrum Wiskunde & Informatica

Language: English

Topic: Mathematical Biology Tumor Growth

Subfield: Modeling and Simulation

Field: Mathematics

Domain: Physical Sciences

Open Access status: bronze

Funders: Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science London, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Japan Society for the Promotion of Science

Awards: G2181256701, G6007741328, Elucidation of a force-dependent mechanism for maintaining radial size of epithelial tubes