Association of amine biomarkers with incident dementia and Alzheimer's disease in the Framingham Study
Year: 2017
Type: article
Study design: Observational Study
Abstract: Introduction The identification of novel biomarkers associated with Alzheimer's disease (AD) could provide key biological insights and permit targeted preclinical prevention. We investigated circulating metabolites associated with incident dementia and AD using metabolomics. Methods Plasma levels of 217 metabolites were assessed in 2067 dementia‐free Framingham Offspring Cohort participants (mean age = 55.9 ± 9.7 years; 52.4% women). We studied their associations with future dementia and AD risk in multivariate Cox models. Results Ninety‐three participants developed incident dementia (mean follow‐up = 15.6 ± 5.2 years). Higher plasma anthranilic acid levels were associated with greater risk of dementia (hazard ratio [HR] = 1.40; 95% confidence interval [CI] = [1.15–1.70]; P = 8.08 × 10−4). Glutamic acid (HR = 1.38; 95% CI = [1.11–1.72]), taurine (HR = 0.74; 95% CI = [0.60–0.92]), and hypoxanthine (HR = 0.74; 95% CI = [0.60–0.92]) levels also showed suggestive associations with dementia risk. Discussion We identified four biologically plausible, candidate plasma biomarkers for dementia. Association of anthranilic acid implicates the kynurenine pathway, which modulates glutamate excitotoxicity. The associations with hypoxanthine and taurine strengthen evidence that uric acid and taurine may be neuroprotective.
Source: Alzheimer s & Dementia
Institutions: Boston University, Inserm, Institut Pasteur de Lille, Centre Hospitalier Universitaire de Lille, Framingham Heart Study, Approches épidémiologiques et moléculaires intégratives visant à améliorer la compréhension des maladies chroniques liées au vieillissement, LabEx DISTALZ, University of Haifa, Vanderbilt University, Vanderbilt University Medical Center, Broad Institute, Harvard University, Massachusetts General Hospital
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1017859460, G1194337659, G1212982470, UC Davis Alzheimer's Disease Core Center, G1353455142, G1379949353, G2004043075, G232440474, G250621538, G278200998, G3109147732, Développement de stratégies innovantes pour une approche transdisciplinaire de la maladie d'Alzheime, G3405256882, G36433118, G412671775, G511441455, G5164707915, G5370164845, G5558075022, G6144706364, MRI, Genetics & Cognitive Precursors of AD and Dementia, The Framingham Heart Study, Metabolomic predictors of insulin resistance and diabetes
OpenAlex ID: W2623652145