The Modulation of Androgen Signaling by Steroid Hormones and Mechanical Tension: A Novel Pathway of Labor Initiation
Year: 2011
Type: dissertation
Abstract: We investigated the gestational expression of androgen receptor (AR) and defined its\nregulation and that of its co-repressors, PSF and p54nrb, by steroid hormones and\nmyometrial stretch in vivo in pregnant and non-pregnant rats. Our data demonstrate\nthat, 1) myometrial AR expression decreases prior to term; 2) AR expression is\nup-regulated by MPA treatment and down-regulated by mechanical stretch; (3)\nmyometrial PSF protein expression is down-regulated by estrogen signaling and by\nmechanical stretch, and up-regulated by androgen signaling; (4) while myometrial PSF\nmRNA expression is also down-regulated by stretch, the regulation by estrogen and P4\non PSF mRNA appear to be opposite to the effects on PSF protein. We conclude that\nthe decreased androgen signaling in late pregnancy (as a result of decreased AR and\nPSF expression mediated by hormonal and mechanical signals) may contribute to the\nmechanisms leading to labor initiation.
Source: TSpace (University of Toronto)
Author: Yun-Qing Li
Language: English
Subfield: Endocrinology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2623832381