Nonpharmacological, Biomechanical Approaches to Control Inflammation in Acute Kidney Injury
Year: 2017
Type: article
Abstract: Inflammation is broadly recognized as an important factor in the pathogenesis of acute kidney injury (AKI), but pharmacological approaches to alleviate inflammation in AKI have been without success in clinical trials. Neuromodulation by nonpharmacological methods is emerging as a novel therapeutic strategy to treat inflammatory diseases. Recently, our group and others have demonstrated that vagus nerve stimulation and pulsed ultrasound ameliorated inflammation via the cholinergic anti-inflammatory pathway (CAP) in various animal models, including renal ischemia-reperfusion injury. Delineating the precise mechanisms by which these methods activate the CAP and ameliorate inflammation is mandatory for the broad clinical application in the future. Novel techniques, such as optogenetics, are expected to elucidate these complex mechanisms.
DOI: 10.1159/000477218
Institution: University of Virginia Health System
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: Leukocyte trafficking in acute renal failure, Tailoring ultrasound technology to explore mechanisms of activation of the splenic neuroimmune axis in attenuating acute organ injury., Sphingolipids in Acute Kidney Injury and Disease Progression, Ultrasound for Non-Invasive Prevention of Acute Kidney Injury
OpenAlex ID: W2624269248