The effect of administration of metformin on lipid profile changes andinsulin resistance in patients with polycystic ovary syndrome
Year: 2007
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Objective: Polycystic ovary syndrome (PCOS) is one of the most common\nmetabolism and endocrine disorders among women. The aim of the present\nstudy was to evaluate the effects of metformin on lipid profile\nchanges, insulin resistance, body mass index (BMI), Ovulation and\npregnancy rates in patients affected by PCO syndrome. Materials and\nMethods: In this randomized controlled study, 200 women aged 20-35\nyears with PCOS were selected. Diagnostic criteria were based on the\ndiagnostic criteria of PCO syndrome in Noterdam meeting in 2003.\nSamples of fasting peripheral blood were taken from all patients to\ntest cholesterol, LDL, HDL, TG, FBS and Insulin before treatment.\nPatients were then divided randomly into two groups. In case group\n(n=100), metformin was prescribed three times a day (1500 mg daily) and\nin control group (n=100), placebo was administered in the same way.\nAfter three months, sample of blood was taken again in order to test\nthe variance of the above mentioned parameters to compare with these\namounts before test. Also, BMI was compared before and after treatment\nin both groups. Results: BMI was 28.81±3.18 and 29.49 ± 4.7\nKg/m2 before treatment in case and control groups respectively. This\nratio changed after treatment to 28.45 ± 2.8 and 29.29 ± 4.8\nKg/m2 in case and control groups respectively (P-value>0.05).\nFSH/insulin ratio was 4.67±0.9 and 5.03±1.3 in case and\ncontrol group respectively, while it changed after treatment to 6.07\n± 1.4 and 5.05 ±1.3 and this difference was significant in\ncase group (P-value=0.0001),but it was no difference in control group.\nIn case group, HDL level increased after treatment from 26.65±9.9\nto 33.19± 9.9 MMoL/L (P-value=0.0001), and Triglyceride level\ndecreased after treatment from 208.96±58.9 to 191.54±55.4\nMMoL/L (P-value=0.004); whereas there was no change in control group.\nLDL and cholesterol levels did not change in both groups. Ovulation\nrate and pregnancy rate were significantly higher in case group than in\ncontrol group (86% vs. 20%) (P-value=0.003) and (40% vs. 11%) (P=0.021)\nrespectively. In addition, Metformin had no significant effect on BMI\nin case group. Conclusion: Treatment with metformin during 3 months\ncauses not only the increase in ovulation and pregnancy rates but also\nthe decrease in insulin resistance and lipid profile changes.
Source: TSpace (University of Toronto)
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2624460084