Year: 2010
Type: dissertation
Study design: Clinical Trial
Abstract: High fibre diets are associated with reduced risk of type 2 diabetes mellitus (T2DM). This may be due to short-chain-fatty-acids (SCFA) influencing insulin resistance and secretion via changes in free-fatty-acids (FFA) and specific gut hormones. We aimed to determine the postprandial effects of inulin, a fermentable, soluble fibre in healthy subjects.\nTwelve fasted subjects were studied for 6 hours after either 80g high fructose corn syrup (HFCS), 56g HFCS plus 24g inulin, or 56g HFCS drinks using a randomized, cross-over design.\nSCFA were higher after inulin beginning at 4 hours. FFA were lower 4 hours after inulin than 56gHFCS. GLP-1 was higher 30 minutes after inulin than 56 and 80HFCS, while ghrelin was lower from 4-6 hours after inulin.\nThe results support the hypothesis that inulin and SCFA generated from colonic fermentation of dietary fibre may improve insulin resistance and secretion via modulation of FFA and specific gut hormones.
Source: TSpace (University of Toronto)
Author: Joshua Tarini
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2624667771