Work

Hypoxia in the glioblastoma microenvironment: shaping the phenotype of cancer stem-like cells

Year: 2016

Type: review

Abstract: Glioblastoma is the most common and aggressive malignant primary brain tumor. Cellular heterogeneity is a characteristic feature of the disease and contributes to the difficulty in formulating effective therapies. Glioma stem-like cells (GSCs) have been identified as a subpopulation of tumor cells that are thought to be largely responsible for resistance to treatment. Intratumoral hypoxia contributes to maintenance of the GSCs by supporting the critical stem cell traits of multipotency, self-renewal, and tumorigenicity. This review highlights the interaction of GSCs with the hypoxic tumor microenvironment, exploring the mechanisms underlying the contribution of GSCs to tumor vessel dynamics, immune modulation, and metabolic alteration.

Source: Neuro-Oncology

DOI: 10.1093/neuonc/now258

Authors: Nicole Colwell, Mioara Larion, Amber J. Giles, Ashlee N. Seldomridge, Saman Sizdahkhani, Mark R. Gilbert, Deric M. Park

Institutions: National Institute of Neurological Disorders and Stroke, National Cancer Institute

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2624969848

FWCI: 0.906

Cites: 97

Cited by: 299

Related to: 10