Work

Introduction

Year: 1999

Type: article

Abstract: Nearly three decades have passed since Sir John Vane correctly hypothesized that nonsteroidal anti-inflammatory drugs (NSAIDs), in wide use mainly for the treatment of pain and inflammation in osteoarthritis and rheumatoid arthritis, act by inhibiting the catalytic activity of the enzyme cyclooxygenase (COX). The chief pitfalls of using these medications are that, while ameliorating pain and inflammation, they also disrupt the homeostatic activities of the prostaglandins formed by COX.

Source: The American Journal of Medicine

DOI: 10.1016/s0002-9343(99)00111-4

Author: Peter E Lipsky

Institution: The University of Texas Southwestern Medical Center

Language: English

Topic: Inflammatory mediators and NSAID effects

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,770