A study of Drosophila Orthodenticle: Mapping the functional domains and proposing a post-developmental role in the Drosophila eye
Year: 2010
Type: article
Abstract: From flies to humans, Orthodenticle (Otd)-related homeodomain transcription factors are necessary for eye development.Vertebrates encode three Otd-related factors, Otx1, Otx2 and Crx, while Drosophila encodes a single factor, Otd.Mutations in Otx2 or Crx can lead to eye diseases by affecting morphogenesis or maintenance of photoreceptors.In the Drosophila eye, Otd has been found to play a conserved role and is likewise necessary for photoreceptor morphogenesis and subtype specification during terminal differentiation.This latter function occurs through cell-specific activation and repression of known target genes.However, the mechanism of how Otd regulates transcription remains unknown.To address this question, we performed an in vitro analysis of Otd to identify functional domains and found that Otd contains two independent activation domains, one at the N and C-terminus, and a potential repression domain centrally located in the protein.These v Table of Contents General Introduction....
Author: Elizabeth C. McDonald
Institution: University of Cincinnati
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2625446164