Year: 2017
Type: article
Abstract: Visualizing disease heterogeneity remains a challenging task since most imaging agents are targeted to a single receptor. We describe the development of an MR platform able to report on multiple molecular events. Enzyme activation and enhanced cellular uptake of this modular probe make it suitable for subsequent targeted-reporter imaging applications.
Source: Chemical Science
DOI: 10.1039/c7sc02217d
Institutions: Case Western Reserve University, Northwestern University
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: diamond
Funders: National Science Foundation, National Aeronautics and Space Administration, National Foundation for Cancer Research, National Institutes of Health, Ames Research Center, Robert H. Lurie Comprehensive Cancer Center, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering
Awards: G1164661550, G1187687215, Cardiovascular Regenerative Medicine, G23745306, G4082334743, G4159268500, Molecular Biophysics Training Program at Northwestern University, q-Modulated Magnetic Resonance Imaging Contrast Agents, G6544658276, INSTITUTE FOR PROTEOMICS AND NANOBIOTECHNOLOGY AT NORTHWESTERN UNIVERSITY IN EVANSTON, IL, G9000036047, G9000106148, The Robert H. Lurie Comprehensive Cancer Center, G991892393
OpenAlex ID: W2625921427