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Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death

Year: 2017
Type: article
Abstract: Stimulator of interferon genes (STING) was initially described as a sensor of intracellular bacterial and viral DNA and a promising adjuvant target in innate immune cells; more recently STING has also been shown to detect endogenous DNA and play a role in tumor immunity and autoimmune disease development. Thus far STING has been studied in macrophages and dendritic cells. In this study, to our knowledge we provide the first evidence of STING activation in T cells, in which STING agonists not only provoke type I IFN production and IFN-stimulated gene expression, mirroring the response of innate cells, but are also capable of activating cell stress and death pathways. Our results suggest a re-evaluation of STING agonist-based therapies may be necessary to identify the possible effects on the T cell compartment. Conversely, the effects of STING on T cells could potentially be harnessed for therapeutic applications.
DOI: 10.4049/jimmunol.1601999
Authors: Bridget Larkin, Vladimir Ilyukha, Maxim Sorokin, Anton Buzdin, Edouard Vannier, Alexander Poltorak
Institutions: Tufts University, Petrozavodsk State University, Kurchatov Institute, Institute of Bioorganic Chemistry, Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Tufts Medical Center
Language: English
Subfield: Immunology
Open Access status: green
Awards: G1082146873, G1287891631, Activation of STING-mediated pathway(s) in T cells, Understanding genetic basis for resistance to TNF-induced lethal shock using new, G717596375, The regulation of basal interferon and its role in necroptosis
OpenAlex ID: W2626019299
FWCI: 10.64
Cites: 21
Cited by: 360
Related to: 10