Work

Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models

Year: 2017

Type: review

Abstract: Parkinson’s disease (PD) is a neurodegenerative disorder with symptoms that progressively worsen with age. Pathologically, PD is characterized by the aggregation of α-synuclein in cells of the substantia nigra in the brain and loss of dopaminergic neurons. This pathology is associated with impaired movement and reduced cognitive function. The etiology of PD can be attributed to a combination of environmental and genetic factors. A popular animal model, the nematode roundworm Caenorhabditis elegans, has been frequently used to study the role of genetic and environmental factors in the molecular pathology and behavioral phenotypes associated with PD. The current review summarizes cellular markers and behavioral phenotypes in transgenic and toxin-induced PD models of C. elegans.

Source: Frontiers in Genetics

DOI: 10.3389/fgene.2017.00077

Authors: Malabika Maulik, Swarup Mitra, Abel Bult-Ito, Barbara E. Taylor, Elena M. Vayndorf

Institutions: University of Alaska Fairbanks, California State University, Long Beach

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801