Year: 2012
Type: dissertation
Study design: Observational Study
Abstract: Emerging evidence from animal and human studies has indicated a potential link between a certain pattern of gut microbiota and adiposity. In the current study, the relationship between gut microbial composition and BMI was further investigated in human with the incorporation of macronutrient consumption and quantification of methanogenic Archaea. BMI was found to be negatively associated with the amount of fecal Bacteroides/Prevotella, E. coli and total bacteria. The intake of carbohydrate and dietary fiber were negatively associated with the amount of C. coccoides, and polyunsaturated fat intake was inversely correlated with the amount of fecal C. leptum, Bacteroides/Prevotella, and total bacteria. Fecal Archaea measured by breath CH4 was positively associated with the amount of fecal E.coli but negatively associated with C. coccoides and log Firmicutes/Bacteroidetes ratio. In conclusion, our findings suggest that fecal bacterial composition is associated with BMI, diet and fecal Archaea.
Source: TSpace (University of Toronto)
Author: Wen Jin Su
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2626148999