Year: 2015
Type: conference-paper
Abstract: As a therapeutic approach to treat arthropathies such as osteoarthritis (OA), regenerative medicine is a promising method. Tissue engineering of the articular cartilage has been challenged by applying chemical and mechanical stimuli to replicate the in vivo environment, however, there are still many problems to be overcome. To synthesize thick cartilage tissues with adequate mechanical properties, it is crucial to supply nutrients and oxygen to the center of the tissues. In this study, we have developed a new method, the multilayer technique to solve this problem. Compared to conventional techniques that make regenerative tissues via single layers, our proposed technique is able to create thicker tissues with better mechanical properties. Further studies are needed to elucidate the underlying mechanism of this technique.
Institution: The University of Tokyo
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2631781760