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Additional file 1: Figure S1. of Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications

Year: 2016

Type: article

Abstract: Showing MCL-1 mRNA levels do not change in Her2-positive BC cells under hypoxic conditions. Figure S2 showing a Bcl-2 is expressed in both Mcl-1wt/wt and Mcl-1Î /null MEFs. Whole-cell extracts were analyzed by immunoblotting with indicated antibodies. Immunoblotting for Erk2 confirmed equal protein loading. b EU-5346 does not change Mcl-1 mRNA expression in Her2-positive BC cells under hypoxic conditions. Figure S3 showing Mcl-1 is a potential therapeutic target not only in Her2-positive, but also in Luminal A-like and TNBC cells under hypoxic conditions. (PDF 1580 kb)

Source: Figshare

DOI: 10.6084/m9.figshare.4405454

Authors: Bashari, Muhammad, Fan, Fengjuan, Vallet, Sonia, Sattler, Martin, Arn, Melissa, Luckner-Minden, Claudia, Schulze-Bergkamen, Henning, ZĂśrnig, Inka, Marme, Frederik, Schneeweiss, Andreas, Cardone, Michael, Opferman, Joseph, JĂ¤ger, Dirk, Podar, Klaus

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2634550822

FWCI:

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