Work

Effect of Genetic Variation inUGT1AandABCB1on Moxifloxacin Pharmacokinetics in South African Patients with Tuberculosis

Year: 2017

Type: article

Study design: Observational Study

Abstract: AIM: We assessed the effect of genetic variability in UGT1A and ABCB1 genes on moxifloxacin pharmacokinetics. METHODS: and high-resolution melt analysis for rs8175347. A nonlinear mixed-effects model was used to describe moxifloxacin pharmacokinetics. RESULTS: Genotypes of UGT1A SNPs, rs8175347 and rs3755319 (20.6% lower and 11.6% increased clearance, respectively) and ABCB1 SNP rs2032582 (40% reduced bioavailability in one individual) were significantly associated with changes in moxifloxacin pharmacokinetic parameters. CONCLUSION: Genetic variation in UGT1A as represented by rs8175347 to a lesser extent rs3755319 and the ABCB1 rs2032582 SNP is modestly associated with the interindividual variability reported in moxifloxacin pharmacokinetics and exposure. Clinical relevance of the effects of genetic variation on moxifloxacin pharmacokinetic requires further investigation.

Source: Pharmacogenomics

DOI: 10.2217/pgs-2017-0144

Authors: Anushka Naidoo, Veron Ramsuran, Maxwell Chirehwa, Paolo Denti, Helen McIlleron, Kogieleum Naidoo, Nonhlanhla Yende-Zuma, Ravesh Singh, Sinaye Ngcapu, Mamoonah Chaudhry, Michael S Pepper, Nesri Padayatchi

Institutions: Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, University of Cape Town, National Health Laboratory Service, South African Medical Research Council, University of Pretoria

Language: English

Topic: Pharmacogenetics and Drug Metabolism

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Health and Human Services, National Research Foundation, South African Medical Research Council, Inyuvesi Yakwazulu-Natali, National Institutes of Health, Medical Research Council, Fogarty International Center, Office of AIDS Research, European and Developing Countries Clinical Trials Partnership, College of Health Sciences, University of KwaZulu-Natal

Awards: G2560876791, G3054758228, G3592516038, G379816909, G4196296179, Columbia University-Southern African AIDS International Training/Research Program, ENHANCING, TRAINING, RESEARCH CAPACITY AND EXPERTISE IN HIV CARE-ENTREE, G997740479

OpenAlex ID: W2637028878

FWCI: 1.163

Cites: 38

Cited by: 28

Related to: 10