Work

Mitochondrial Myopathy: A Rare Cause of Early-Onset Vocal Fold Atrophy

Year: 2013

Type: article

Abstract: OBJECTIVES: We present the second published case of laryngeal involvement in mitochondrial myopathy. METHODS: A patient with laryngeal involvement of mitochondrial myopathy is presented, together with a literature review. RESULTS: A 41-year-old man presented with progressive breathy dysphonia. His brother had mitochondrial myopathy. Biopsy of the biceps muscle demonstrated cytochrome C oxidase-negative ragged blue fibers confirming mitochondrial myopathy. Videostroboscopy showed marked vocal fold atrophy, but subsequent injection laryngoplasty did not significantly improve the patient's voice, despite improved postoperative glottic closure. CONCLUSIONS: Mitochondrial myopathy should be considered in the differential diagnosis of severe early-onset vocal fold atrophy.

Source: Annals of Otology Rhinology & Laryngology

DOI: 10.1177/000348941312200306

Authors: Elizabeth A. Kelly, Jonathan M. Bock, Amanda C. Peltier, Shin J. Oh, C. Gaelyn Garrett

Institutions: Medical College of Wisconsin, University of Alabama at Birmingham, Vanderbilt University Medical Center, Vanderbilt University

Language: English

Topic: Voice and Speech Disorders

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Center for Advancing Translational Sciences