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The double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants

Year: 2017
Type: article
Abstract: nanoLC-MS/MS. A tentative mechanism for the degradation was proposed and validated with model peptides. In addition, we performed electrophysiological analysis to investigate the synaptic functions in brain slices, and found that in the presence of a significant excess of vitamin C, Cu(ii) could prevent an Aβ-induced deficit in synaptic transmission in the hippocampus. Collectively, our evidence strongly indicated that a proper combination of copper and anti-oxidants might have a positive effect on the prevention of AD. This double-edged function of copper in AD has been largely overlooked in the past. We believe that our report is very important for fully understanding the function of copper in AD pathology.
DOI: 10.1039/c7sc01787a
Authors: Jing Yang, Xueli Zhang, Yiying Zhu, Emily Lenczowski, Yanli Tian, Jian Yang, Can Zhang, Markus Hardt, Chunhua Qiao, Rudolph E. Tanzi, Anna Moore, Hui Ye, Chongzhao Ran
Institutions: Harvard University, Soochow University, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts Institute of Technology, China Pharmaceutical University, The Forsyth Institute, Loyola University Chicago, Sun Yat-sen University
Language: English
Subfield: Physiology
Field: Medicine
Open Access status: diamond
OpenAlex ID: W2658498731
FWCI: 1.822
Cites: 77
Cited by: 23
Related to: 10