Work

MiR-34a inhibits oral cancer progression partially by repression of interleukin-6-receptor.

Year: 2015

Type: article

Abstract: Previous reports revealed that a significant decrease of miR-34a in oral cancer. But the role of miR-34a in oral cancer needs further research. In the present study, we will investigate the effect of miR-34a on oral cancer cell phenotypes. First, it was verified that miR-34a expression was lower in oral cancer tissues compared with their normal controls, so did the oral cancer cells. Next, it was showed that miR-34a overexpression in oral cancer cells could inhibit cell proliferation, G1 phase arrest, metastasis and epithelial mesenchymal transition. It was predicted that interleukin-6-receptor (IL6R) was a potential target gene of miR-34a by bioinformatics analysis and identified by luciferase assay. It was further showed that miR-34a inhibited oral cancer progression via IL6R. Collectively, our findings suggested that miR-34a may function as a tumor suppressor in oral cancer by targeting IL6R.

Source: Europe PMC (PubMed Central)

Authors: Ting Li, Lichu Li, Dongshuang Li, Shuting Wang, Jinhu Sun

Institutions: Xuzhou Medical College, Guangxi Medical University, Affiliated Hospital of Xuzhou Medical College

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W266390847

FWCI: 0.518

Cites: 27

Cited by: 26

Related to: 10