Work

Chemokine receptor-like 2 is involved in ischemic brain injury

Year: 2013

Type: article

Abstract: mouse stroke models. The expression of CCRL2 was enhanced at both the RNA and protein levels in cultured brain slices under ischemic conditions. Ischemia-induced cell death was reduced in brain slices derived from CCRL2 knockout (KO) mice in comparison with those from wild type (WT) mice. The infarct volume was smaller and neurological deficits were attenuated in CCRL2 KO mice when compared to WT mice subjected to a transient middle cerebral artery occlusion. Our data suggest that CCRL2 is involved in ischemia-induced brain injury in mice.

Source: Journal of Experimental Stroke and Translational Medicine

DOI: 10.4172/1939-067x.1000141

Authors: Robert M Douglas, Alice H Chen, Alejandra Iniguez, Juan Wang, Zhengxing Fu, Frank L Powell Jr, Gabriel G Haddad, Hang Yao

Institutions: University of California San Diego, Rady Children's Hospital-San Diego

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Institutes of Health, University of California, San Diego, National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G2033464147, G2041273731, G3033040839, G4811985280, University of California San Diego Neuroscience Microscopy Imaging Core, G639426234, G83128408, G9000255603

OpenAlex ID: W26724025

FWCI: 0.642

Cites: 24

Cited by: 9

Related to: 10