Work

Quinone-fused porphyrins as contrast agents for photoacoustic imaging

Year: 2017

Type: article

Abstract: . In this context, the highest PA signal was obtained with a Zn(ii) inserted dye. Furthermore, this dye was stable in blood serum and free thiol solution and exhibited negligible cell toxicity. Additionally, the Zn(ii) probe could be detected with an up to 3.2 fold higher PA intensity compared to the clinically most commonly used PA agent, ICG. Thus, further exploration of the 'quinone-fusing' approach to other chromophores may be an efficient way to generate highly potent PA agents that do not fluoresce and shift their absorption into the NIR range.

Source: Chemical Science

DOI: 10.1039/c7sc01369h

Authors: Srinivas Banala, Stanley Fokong, Christian Brand, Chrysafis Andreou, Bernhard Kräutler, Magnus Rueping, Fabian Kiessling

Institutions: RWTH Aachen University, Memorial Sloan Kettering Cancer Center, Universität Innsbruck, King Abdullah University of Science and Technology

Language: English

Topic: Porphyrin and Phthalocyanine Chemistry

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: diamond

OpenAlex ID: W2683674709

FWCI: 3.811

Cites: 37

Cited by: 58

Related to: 10