Biomaterials and the Foreign Body Reaction: Surface Chemistry Dependent Macrophage Adhesion, Fusion, Apoptosis, and Cytokine Production
Year: 2007
Type: article
Abstract: The foreign body reaction has proven to be a hindrance to the functionality of implanted biomedical devices.The ability to direct this reaction, inflammation, and wound healing via the material-dependent control of key cellular components, macrophages and foreign body giant cells (FBGCs), is vital to the development of future biomedical devices.This dissertation addresses the hypothesis that surface chemistry directs adherent macrophage/FBGC behavior.Table 1.2 Water Contact Angles of Clinically and Experimentally Utilized Polymers 11,12 Material Relative Hydrophobicity Contact Angles ( o ) Relative Cell Attachment Clinically Used Polymers* PFTE -Polytetrafluoroethylene Very Hydrophobic 105-116 Nonadhesive PDMS -Poly(dimethyl siloxane) Very Hydrophobic 100-104 Nonadhesive PE -Polyethylene Hydrophobic 92-97 Nonadhesive PP -Polypropylene Hydrophobic 92-97 Nonadhesive PS -Polystyrene Hydrophobic 75-91 Nonadhesive PC -Polycarbonates Hydrophobic 95 Adhesive PMMA -Poly(methyl methacrylate) Intermediate 65-80 Adhesive PU -Polyurethane Intermediate 60 Adhesive PET -Poly(ethylene terephthalate) Intermediate 65-81 Adhesive TCPS -Tissue culture polystyrene Hydrophilic 35-68 Adhesive p-HEMA -Poly(hydroxyethyl methacrylate) Hydrophilic 60-80 Conditionally (non)adhesive PEO -Poly(ethylene oxide Hydrophilic 20-45 Conditionally (non)adhesive Photografted Polymers^ PET -Poly(ethylene terephthalate) Intermediate 71 Adhesive BDEDTC -Modified poly(ethylene terephthalate) Intermediate 68 Adhesive PAAm-Modified poly(ethylene terephthalate) Hydrophilic 46 Conditionally (non)adhesive PAANa -Modified poly(ethylene terephthalate) Hydrophilic 24 Conditionally (non)adhesive DMAPAAmMeI -Modified poly(ethylene terephthalate) Hydrophilic 31 Conditionally (non)adhesive Polyurethanes^ Elasthane 80A -Polyether urethane Intermediate 61 Adhesive Bionate 80A -Polycarbonate urethane Intermediate 62 Adhesive PurSil 20 80A -PDMS modified polyether urethane Hydrophobic 90 Adhesive CarboSil 20 90A -PDMS modified polycarbonate urethane Hydrophobic 92 Adhesive Elasthane 80A-F -Fluorocarbon modified polyether urethane Very Hydrophobic 109 Nonadhesive Elasthane 80A-P -Polyethylene oxide modified polyether urethane Intermediate 62 Adhesive * Adapted from references [11,12].^ See Chapters II and V for detailed description of the materials and contact angle analysis.formation.Normalizing the ELISA data based on the adherent cell population provided cytokine/chemokine concentrations produced per cell.This analysis showed that although there were fewer cells on the hydrophilic/neutral surface, these adherent cells were further activated to produce significantly greater amounts of each cytokine/chemokine tested than the other surfaces.This study clearly presents evidence that material surface chemistry can differentially affect monocyte/macrophage/FBGC adhesion and cytokine/chemokine profiles derived from activated macrophages/FBGCs adherent to biomaterial surfaces.
Author: Jacqueline A. Jones
Institution: Case Western Reserve University
Language: English
Subfield: Surfaces, Coatings and Films
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W269128656