Year: 1999
Type: article
Abstract: Graphical analysis refers to the transformation of multiple time measurements of plasma and tissue uptake data into a linear plot, the slope of which is related to the number of available tracer binding sites. This type of analysis allows easy comparisons among experiments. No particular model structure is assumed, however it is assumed that the tracer is given by bolus injection and that both tissue uptake and the plasma concentration of unchanged tracer are monitored following tracer injection. The requirement of plasma measurements can be eliminated in some cases when a reference region is available. There are two categories of graphical methods which apply to two general types of ligands--those which bind reversibly during the scanning procedure and those which are irreversible or trapped during the time of the scanning procedure.
Author: Jean Logan
Institution: Brookhaven National Laboratory
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2698045512