Work

The role of GTP in prostaglandin E1 stimulation of adenylate cyclase in platelet membranes

Year: 1983

Type: article

Abstract: Adenylate cyclase activity in platelet membrane preparations was measured in the presence of prostaglandin E1 (PGE1), GTP and a non-hydrolysable analogue of GDP, guanosine 5'-[beta-thio]diphosphate (GDP[beta S]). A dose-dependent inhibition of adenylate cyclase by GDP[beta S] was observed that could be reversed either by adding increased amounts of GTP or of PGE1.

Source: Biochemical Journal

DOI: 10.1042/bj2140231

Authors: J M Stein, B R Martin

Institution: University of Cambridge

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W269806918