Formation and Degradation of Microscopic Globular Body : A Proteinaceous Spheron Originated from Dendrite
Year: 2013
Type: article
Abstract: Microscopic globular bodies （MGBs） are eosinophilic spherical inclusions, 1-10 μm in diameter and are located in dendrites. Although MGBs are distributed widely in the gray matter, they are most frequent and numerous in the cerebral neocortex and hippocampus. They are found in the human subjects with and without neurological diseases, ranging in age from 1 to 99 years. Previous histochemical studies have shown that MGBs consist of a proteinaceous component. Recently, we immunohistochemically examined the hippocampus from five control subjects. The marginal portion of MGBs was positive for lysosomal proteases（ cathepsins B, D and L）, and markers of dendrite（ MAP2） and dendritic spine（ drebrin）. They were negative for ubiquitin, ubiquitin-proteasome system （p62, NUB1 and EDD1）, autophagosome （LC3）, cytoskeletal proteins （neurofilament, actin, tubulin and cytokeratin）, tau, α-synuclein and TDP-43. These findings suggest that MGBs are sequestered by lysosome-protease\nsystem, but not by ubiquitin-proteasome system or autophagosome.
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funder: Hirosaki University
OpenAlex ID: W2721124546