Work

Benzothiazole Sulfinate: A Sulfinic Acid Transfer Reagent under Oxidation-Free Conditions

Year: 2017

Type: article

Abstract: Sulfinic acids are commonly encountered intermediates found in natural product synthesis and medicinal chemistry. However, because of high reactivity, instability, and harsh reaction conditions, they are difficult to synthesize. Herein we have developed an oxidation-free method to produce sulfinic acids and sulfinate salts using 2-sulfinyl benzothiazole (BTS). We have also demonstrated the synthetic usefulness by developing one-pot syntheses of sulfones and sulfonamides.

Source: Organic Letters

DOI: 10.1021/acs.orglett.7b01693

Authors: Jacob J. Day, Deshka L. Neill, Shi Xu, Ming Xian

Institution: Washington State University

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Heart, Lung, and Blood Institute

Award: Novel Sulfur Dioxide Donors and Their Cardioprotective Effects