Year: 2017
Type: article
Abstract: African Americans have higher rates of asthma prevalence, morbidity, and mortality in comparison with other racial groups. We sought to characterize endotypes of childhood asthma severity in African American patients in an inner-city pediatric asthma population. Baseline blood neutrophils, blood eosinophils, and 38 serum cytokine levels were measured in a sample of 235 asthmatic children (6-17 years) enrolled in the NIAID (National Institute of Allergy and Infectious Diseases)-sponsored Asthma Phenotypes in the Inner City (APIC) study (ICAC (Inner City Asthma Consortium)-19). Cytokines were quantified using a MILLIPLEX panel and analyzed on a Luminex analyzer. Patients were classified as Easy-to-Control or Difficult-to-Control based on the required dose of controller medications over one year of prospective management. A multivariate variable selection procedure was used to select cytokines associated with Difficult-to-Control versus Easy-to-Control asthma, adjusting for age, sex, blood eosinophils, and blood neutrophils. In inner-city African American children, 12 cytokines were significant predictors of Difficult-to-Control asthma (n = 235). CXCL-1, IL-5, IL-8, and IL-17A were positively associated with Difficult-to-Control asthma, while IL-4 and IL-13 were positively associated with Easy-to-Control asthma. Using likelihood ratio testing, it was observed that in addition to blood eosinophils and neutrophils, serum cytokines improved the fit of the model. In an inner-city pediatric population, serum cytokines significantly contributed to the definition of Difficult-to-Control asthma endotypes in African American children. Mixed responses characterized by TH2 (IL-5) and TH17-associated cytokines were associated with Difficult-to-Control asthma. Collectively, these data may contribute to risk stratification of Difficult-to-Control asthma in the African American population.
Source: PLoS ONE
Institutions: Cincinnati Children's Hospital Medical Center, University of Cincinnati, Rho (United States), Johns Hopkins University, Boston University, Lurie Children's Hospital, The University of Texas Southwestern Medical Center, Henry Ford Health, Columbia University, Children's National, University of Wisconsin–Madison, National Institute of Allergy and Infectious Diseases, National Jewish Health, Children's Hospital Colorado, University of Colorado Anschutz
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,382
Awards: G1160208864, G11701374, G1260873166, UT Southwestern Center for Translational Medicine (UL1/KL2/TL1), G1946127298, Colorado Clinical and Translational Science Institute (UL1), G2510601091, G2663179255, G2707217263, G277117613, Clinical and Translational Science Institute at Children's National, G4325039693, G475936976, G491532010, Inner City Asthma consortium 3 (ICAC3), UT-Southwestern Clinical and Translational Alliance for Research (UT-STAR) (TL1), Colorado Clinical and Translational Sciences Institute, G629043820, Institute for Clinical and Translational Research, G7374553457, G7480681299, G766751244, Clinical and Translational Science Award, G8905806635, G9000001959, G9000020237, G9000070888, G9000130953, G9000233576, G972384021
OpenAlex ID: W2726897620