Prediction of Long-term Cognitive Decline Following Delirium in Older Adults
Year: 2017
Type: conference-abstract
Abstract: Postoperative delirium has been linked to long-term cognitive decline in older adults, but this area remains under-explored. We examined pre-surgical factors in risk groups (demographic, lifestyle, cognitive/physical/sensory/mental function, frailty, medical factors, biomarkers) associated with long-term cognitive decline among 134 SAGES participants who developed delirium. Using multivariable approaches, we identified explanatory factors that accounted for variability in rates of cognitive decline in an overall model incorporating factors across groups. Baseline General Cognitive Performance (GCP) score (composite score incorporating 9 neuropsychological tests) explained the most variation in cognitive decline (10.0%), and 6 factors—lower GCP, impaired IQCODE, living alone, slow walking, less exhaustion, and orthopedic surgery—combined to explain 25% of variation in cognitive decline. Thus, pre-surgical factors predict long-term cognitive decline following delirium, with the predictive value comparing favorably to prior studies. Such predictive models will be critical to target high risk older surgical patients for preventive and therapeutic approaches.
Source: Innovation in Aging
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,977
OpenAlex ID: W2727279590