Work

Trajectories of Grip Strength, Cardiometabolic Risk Factors, and Disability on Older Adults

Year: 2017

Type: conference-abstract

Abstract: Objective. To examine cardiometabolic risk factors as potential intervening mechanism in the association between trajectories of grip strength and functional disability in older adults. Methods. Data came from ~3200 adults (≥65 years of age) from the HRS Study observed for up to 8 years. Hierarchical linear models assessed how changes in grip strength and cardiometabolic factors (HDL-cholesterol, HbA1c, C-reactive protein, and cystatin-C) are associated with a combined ADL/IADL index of functional disability. Analyses were performed stratified by gender. Results. GS declined over 8 years following a linear trajectory. Decline in grip strength predicted an increase in the burden of functional disability in both men and women. Cardiometabolic factors (except cystatin-C) were associated with the rate of decline in grip strength and partially mediated the association with functional disability. Implications. Cardiometabolic factors should be investigated as potential targets for reducing the burden of disability associated with muscle weakness in older adults.

Source: Innovation in Aging

DOI: 10.1093/geroni/igx004.4748

Authors: A. Botoseneanu, B.A. Shaw, H. Murayama, J. Liang

Institutions: University of Michigan, University at Albany, State University of New York, Institute of Gerontology, The University of Tokyo, The University of Tokyo

Language: English

Topic: Nutrition and Health in Aging

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,977