Work

A Small Viral PPxY Peptide Motif To Control Antiviral Autophagy

Year: 2017

Type: review

Abstract: Autophagy is an essential metabolic program that is also used for clearing intracellular pathogens. This mechanism, also termed selective autophagy, is well characterized for invasive bacteria but remains poorly documented for viral infections. Here we highlight our recent work showing that endosomolytic adenoviruses trigger autophagy when entering cells. Our study revealed how adenoviruses exploit a capsid-associated small PPxY peptide motif to manipulate the autophagic machinery to prevent autophagic degradation and to promote endosomal escape and nuclear trafficking.

Source: Journal of Virology

DOI: 10.1128/jvi.00581-17

Authors: Charlotte Montespan, Christopher M. Wiethoff, Harald Wodrich

Institutions: Centre National de la Recherche Scientifique, Université de Bordeaux, Laboratoire de Microbiologie Fondamentale et Pathogénicité, Eli Lilly (United States)

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Institut National de la Santé et de la Recherche Médicale