Work

Pharmacokinetics of Monoclonal Antibodies

Year: 2017

Type: review

Abstract: Monoclonal antibodies (mAbs) have developed in the last two decades into the backbone of pharmacotherapeutic interventions in a variety of indications, with currently more than 40 mAbs approved by the US Food and Drug Administration, and several dozens more in clinical development. This tutorial will review major drug disposition processes relevant for mAbs, and will highlight product-specific and patient-specific factors that modulate their pharmacokinetic (PK) behavior and need to be considered for successful clinical therapy.

Source: CPT Pharmacometrics & Systems Pharmacology

DOI: 10.1002/psp4.12224

Authors: Josiah T. Ryman, Bernd Meibohm

Institution: University of Tennessee Health Science Center

Language: English

Topic: Monoclonal and Polyclonal Antibodies Research

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,140