Dclk1-expressing tuft cells: critical modulators of the intestinal niche?
Year: 2017
Type: review
Abstract: -expressing tuft cells constitute a unique intestinal epithelial lineage that is distinct from enterocytes, Paneth cells, goblet cells, and enteroendocrine cells. Tuft cells express taste-related receptors and distinct transcription factors and interact closely with the enteric nervous system, suggesting a chemosensory cell lineage. In addition, recent work has shown that tuft cells interact closely with cells of the immune system, with a critical role in the cellular regulatory network governing responses to luminal parasites. Importantly, ablation of tuft cells severely impairs epithelial proliferation and tissue regeneration after injury, implicating tuft cells in the modulation of epithelial stem/progenitor function. Finally, tuft cells expand during chronic inflammation and in preneoplastic tissues, suggesting a possible early role in inflammation-associated tumorigenesis. Hence, we outline and discuss emerging evidence that strongly supports tuft cells as key regulatory cells in the complex network of the intestinal microenvironment.
Language: English
Topic: IL-33, ST2, and ILC Pathways
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating Center, G189118987, Quiescent Dclk1+ stem cells in the mouse intestine, Regulatory mechanism of gastric differentiation from gastric stem cells, Enteroendocrine Cell Subsets with Reserve Stem Cell Function, Regulation of Active and Quiescent Intestinal Stem Cells, Intestinal Stem Cell Consortium Coordinating Center
OpenAlex ID: W2728214347