Year: 2015
Type: review
Abstract: In the Spring of 2013, NMR spectroscopists convened at the Weizmann Institute in Israel to brainstorm on approaches to improve the sensitivity of NMR experiments, particularly when applied in biomolecular settings. This multi-author interdisciplinary Review presents a state-of-the-art description of the primary approaches that were considered. Topics discussed included the future of ultrahigh-field NMR systems, emerging NMR detection technologies, new approaches to nuclear hyperpolarization, and progress in sample preparation. All of these are orthogonal efforts, whose gains could multiply and thereby enhance the sensitivity of solid- and liquid-state experiments. While substantial advances have been made in all these areas, numerous challenges remain in the quest of endowing NMR spectroscopy with the sensitivity that has characterized forms of spectroscopies based on electrical or optical measurements. These challenges, and the ways by which scientists and engineers are striving to solve them, are also addressed.
Authors: Jan‐Henrik Ardenkjaer‐Larsen, Gregory S. Boebinger, Arnaud Comment, Simon Duckett, Arthur S. Edison, Frank Engelke, Christian Griesinger, Robert G. Griffin, Christian Hilty, Hidaeki Maeda, Giacomo Parigi, Thomas Prisner, Enrico Ravera, Jan van Bentum, Shimon Vega, Andrew Webb, Claudio Luchinat, Harald Schwalbe, Lucio Frydman
Institutions: Hvidovre Hospital, Copenhagen University Hospital, Technical University of Denmark, Florida State University, National High Magnetic Field Laboratory, École Polytechnique Fédérale de Lausanne, University of York, University of Florida, Bruker (Germany), Max Planck Institute for Biophysical Chemistry, Massachusetts Institute of Technology, Texas A&M University, RIKEN, University of Florence, Goethe University Frankfurt, Radboud University Nijmegen, Weizmann Institute of Science, Leiden University Medical Center
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Funders: National Science Foundation, National High Magnetic Field Laboratory, European Commission, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Ministero dell’Istruzione, dell’Università e della Ricerca, National Institutes of Health, Engineering and Physical Sciences Research Council, Israeli Centers for Research Excellence, Planning and Budgeting Committee of the Council for Higher Education of Israel, National Institute of Biomedical Imaging and Bioengineering, Division of Materials Research, High Magnetic Field Laboratory, Chinese Academy of Sciences, FP7 Ideas: European Research Council
Awards: Signal Amplification in NMR and MRI using hyperpolarised compounds, G2294341347, G2386482098, G244242019, G2646288592, Reaction monitoring on micro-second timescales by nuclear magnetic resonance: aiming for a paradigm shift in the study of reaction mechanisms, G3235069502, Development of a Dynamic Nuclear Polarisation based NMR techniques for the rapid detection and characterisation of reaction intermediates., NMR for Structural Biology, G4624992917, G496205333, G502626589, National High Magnetic Field Laboratory Renewal 2013-2017, G5711520822, G6051118695, G6412891576, Hyperpolarization techniques for biomedical applications, G6561220925, Ultrafast Hyperpolarized NMR and MRI in Multiple Dimensions, G7041737535, A paradigm shift in low-field NMR spectroscopy for industrial process monitoring, control, and optimisation, Signal Amplification in MR achieved through novel inorganic templates, Improved NMR Technology for Natural Products and Metabolomics.
OpenAlex ID: W2144176808