Work

Exploring and Exploiting Proteome Organization during Viral Infection

Year: 2017

Type: article

Abstract: Viral replication in eukaryotes is a process inherently organized in both space and time. Viral components target subcellular organelles to access host machineries required for replication and spread. Diverse viruses are known to alter organelle shape, composition, function, and dynamics as part of their replication cycles. Here, we highlight recent advances in microscopy and proteomic methods that have helped and will continue to help define mechanisms used by viruses to exploit host proteome organization.

Source: Journal of Virology

DOI: 10.1128/jvi.00268-17

Authors: Pierre M. Jean Beltran, Katelyn C. Cook, Ileana M. Cristea

Institution: Princeton University

Language: English

Topic: Advanced Proteomics Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Edward Mallinckrodt, Jr. Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences

Awards: Predoctoral Training in Genetics and Molecular Biology, Functional investigation of the TBX20 cardiac interactome, G2568872698, Mechanisms mediating immune response upon sensing of nuclear viral DNA, G8326871404