Year: 2017
Type: conference-abstract
Abstract: Most observational studies of human aging suffer from confounding, but establishing links between inherited genetic variation and human aging can provide robust insights. Genetic evidence can help identify both biological pathways and also help prove the importance of environmental and behavioral risks. In this symposium, we will present work from a near global collaboration across the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, the European Longevity consortium, and the Chinese Longitudinal Healthy Longevity Study as well as data from the UK Biobank investigating large human samples and unique aging phenotypes to facilitate gene discovery and uncover insights into aging biology. Dr. Joris Deelen will present a 1000 Genome meta-analysis of a novel longevity phenotype defined using age, gender and country specific survival thresholds. Drs. Luke Pilling and Janice Atkins will present data from analyses of parental age at death in nearly 500,000 middle-aged offspring. Novel variants including one in the DNA repair pathway were identified and follow-up analyses to explore mechanisms underlying human aging will be presented. Dr. Daniel Evans will present the Longevity Genomics project and website, a resource to develop translational strategies to promote longevity. The overall project approach is to use longevity associated variants identified from GWAS, gene expression studies and evidence from animal models to identify longevity genes. Mendelian Randomization approaches will be used to evaluate the impact of longevity genes on outcomes and as potential targets for therapeutics.
Source: Innovation in Aging
Authors: J. Murabito, D. Melzer
Institutions: Boston University, University of Exeter
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,977
OpenAlex ID: W2729564708