Melatonin prevents sleep deprivation-associated anxiety-like behavior in rats: role of oxidative stress and balance between GABAergic and glutamatergic transmission.
Year: 2017
Type: article
Abstract: /calmodulin-dependent protein kinase II-alpha in SD rats. Meanwhile, melatonin blocked the down-regulation of γ-aminobutyric acid A-alpha-2 receptor. In conclusion, our results suggest that melatonin prevents anxiety-like behavior induced by SD. The possible mechanism may be attributed to its ability to reduce oxidative stress and maintain balance between GABAergic and glutamatergic transmission.
Source: Europe PMC (PubMed Central)
Authors: Lei Zhang, Hong-Liang Guo, Hu-Qin Zhang, Tian-Qi Xu, Bing He, Zhen-Hai Wang, Yi-Peng Yang, Xiao-Dan Tang, Peng Zhang, Fang-E Liu
Institutions: Xi'an Peihua University, Xi'an Jiaotong University
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2730242959