Work

Autoantibody profiling on a plasmonic nano-gold chip for the early detection of hypertensive heart disease

Year: 2017

Type: article

Abstract: Significance Hypertension affects one in four adults in the United States and is a major risk factor for heart failure. A plasmonic nano-gold platform with excellent reproducibility and sensitivity is developed to address the currently unmet need of profiling circulating cardiovascular autoantibodies in hypertensive patients. We observed that patients with early-stage hypertensive heart diseases displayed a higher level of cardiovascular autoantibodies than hypertensive patients with normal cardiac function. Autoantibodies to troponin I, adrenergic beta-1 receptor, and annexin-A5 could best discriminate hypertensive heart disease. Ultimately, this nanoscience-based platform could be deployed to facilitate screening autoantibodies and identify at-risk patients for early stages of heart failure. Furthermore, this platform could have broad applications in myocarditis, heart transplantation, and other autoimmune diseases.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1621457114