Correction: The complex genetics of gait speed: genome-wide meta-analysis approach
Year: 2017
Type: erratum
Abstract: Applying HaploReg v4.1 analysis to the 536 variants resulted in 9 categories (Supplementary Table 8): miscRNA (1 variant); snoRNA (2 variants); microRNA (4 variants); snRNA (9 variants); pseudogenes (14 variants); sequencing in progress (43 variants); LINC RNA (86 variants); and 372 variants within protein coding genes. In addition, some variants annotate to the same gene resulting in a total of 139 genes (protein-coding or non-coding). Of those genes, 6 are exceptionally long, containing over a million base-pairs, the longest of which is PTPRT coded by 1117219bp. The shortest genes are the ones coding for micro (MIR3143) or small nuclear (U7) RNAs at 63bp each. There is only partial information regarding the chromatin state of each variant. However, from the information gathered in the analysis we observed 14 transcription start sites and 245 enhancers (Supplementary Table 8).
Source: Aging
Authors: Dan Ben-Avraham, David Karasik, Joe Verghese, Kathryn L. Lunetta, Jennifer A. Smith, John D. Eicher, Rotem Vered, Joris Deelen, Alice M. Arnold, Aron S. Buchman, Toshiko Tanaka, Jessica D. Faul, Maria Nethander, Myriam Fornage, Hieab H. Adams, Amy M. Matteini, Michele L. Callisaya, Albert V. Smith, Lei Yu, Philip L. De Jager, Denis A. Evans, Vilmundur Gudnason, Albert Hofman, Alison Pattie, Janie Corley, Lenore J. Launer, Davis S. Knopman, Neeta Parimi, Stephen T. Turner, Stefania Bandinelli, Marian Beekman, Danielle Gutman, Lital Sharvit, Simon P. Mooijaart, David C. Liewald, Jeanine J. Houwing-Duistermaat, Claes Ohlsson, Matthijs Moed, Vincent J. Verlinden, Dan Mellström, Jos N. van der Geest, Magnus Karlsson, Dena Hernandez, Rebekah McWhirter, Yongmei Liu, Russell Thomson, Gregory J. Tranah, Andre G. Uitterlinden, David R. Weir, Wei Zhao, John M. Starr, Andrew D. Johnson, M. Arfan Ikram, David A. Bennett, Steven R. Cummings, Ian J. Deary, Tamara B. Harris, Sharon L. R. Kardia, Thomas H. Mosley, Velandai K. Srikanth, Beverly G. Windham, Ann B. Newman, Jeremy D. Walston, Gail Davies, Daniel S. Evans, Eline P. Slagboom, Luigi Ferrucci, Douglas P. Kiel, Joanne M. Murabito, Gil Atzmon
Institutions: Albert Einstein College of Medicine, Beth Israel Deaconess Medical Center, Bar-Ilan University, Hebrew SeniorLife, Boston University, Framingham Heart Study, University of Michigan, National Heart, Lung, and Blood Institute, University of Haifa, Leiden University Medical Center, Max Planck Institute for Biology of Ageing, University of Washington, Rush University Medical Center, National Institute on Aging, Institute for Social Research, University of Gothenburg, The University of Texas Health Science Center at Houston, Erasmus MC, Johns Hopkins University, Johns Hopkins Medicine, University of Tasmania, Peninsula Health, Menzies Institute for Medical Research, University of Iceland, Icelandic Heart Association, Broad Institute, Brigham and Women's Hospital, Harvard University, Massachusetts Institute of Technology, California Pacific Medical Center, University of Edinburgh, National Institutes of Health, Mayo Clinic, Azienda Sanitaria di Firenze, University of Leeds, Lund University, Wake Forest University Health Sciences, Wake Forest University, Western Sydney University, Netherlands Consortium for Healthy Ageing, Alzheimer Scotland, University of Mississippi Medical Center, University of Pittsburgh
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2732070097