Parvalbumin-Positive Interneurons Regulate Neuronal Ensembles in Visual Cortex
Year: 2017
Type: article
Abstract: For efficient cortical processing, neural circuit dynamics must be spatially and temporally regulated with great precision. Although parvalbumin-positive (PV) interneurons can control network synchrony, it remains unclear how they contribute to spatio-temporal patterning of activity. We investigated this by optogenetic inactivation of PV cells with simultaneous two-photon Ca2+ imaging from populations of neurons in mouse visual cortex in vivo. For both spontaneous and visually evoked activity, PV interneuron inactivation decreased network synchrony. But, interestingly, the response reliability and spatial extent of coactive neuronal ensembles during visual stimulation were also disrupted by PV-cell suppression, which reduced the functional repertoire of ensembles. Thus, PV interneurons can control the spatio-temporal dynamics of multineuronal activity by functionally sculpting neuronal ensembles and making them more different from each other. In doing so, inhibitory circuits could help to orthogonalize multicellular patterns of activity, enabling neural circuits to more efficiently occupy a higher dimensional space of potential dynamics.
Source: Cerebral Cortex
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: G2321596477, G2844466896, G3815095219, G4012432327, Functional consequences of GABAergic inhibition of dendritic spines at puberty, Imaging Functional Connectivity in Visual Cortex, Functional connectomics of the neocortical microcircuit, Multiplexed neuronal activity during flexible decision making, Optical approach to investigate brain mechanisms underlying cognition and visual system, Two-photon optical control of astrocytic function
OpenAlex ID: W2732455748