Mother-daughter concordance in putamen response to loss as a mechanism underlying the intergenerational transmission of depression
Year: 2016
Type: other
Abstract: Background: Maternal history of depression increases the risk that daughters will develop depression, although the mechanisms underlying the intergenerational transmission of this increased risk are not well understood. In this context, researchers have documented structural neural concordance between mothers and daughters in patterns of cortical thickness and volumes of corticolimbic gray matter (Foland-Ross et al., 2016; Yamagata et al., 2016). In this study we used fMRI to investigate mother-daughter functional neural concordance during anticipation of reward gain and loss. Conclusions: This is the first demonstration of neural functional concordance between depressed mothers and their daughters. These findings may have important implications for understanding the intergenerational transmission of depression, highlighting the putamen as a possible region of susceptibility for the development of disorder in daughters of depressed mothers.
Institution: Stanford University
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W2732890273