Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress
Year: 2017
Type: article
Abstract: -loops and cytosolic ssDNA. Transcriptional profiling of cDKO HSPCs revealed the activation of p53 and interferon (IFN) pathways, which enforced cell cycling in quiescent HSPCs, resulting in their apoptotic death. The rapid cell death phenotype was reproducible in in vitro cultured cDKO-hematopoietic stem cells, which were significantly rescued by nucleotide supplementation or after depletion of p53. Collectively, Ssb1 and Ssb2 control crucial aspects of HSPC function, including proliferation and survival in vivo by resolving replicative stress to maintain genomic stability.
Source: Blood
Authors: Wei Shi, Therese Vu, Didier Boucher, Anna Biernacka, Jules Nde, Raj K. Pandita, Jasmin Straube, Glen M. Boyle, Fares Al-Ejeh, Purba Nag, Jessie Jeffery, Janelle L. Harris, Amanda L. Bain, Marta Grzelak, Magdalena Skrzypczak, Abhishek Mitra, Norbert Dojer, Nicola Crosetto, Nicole Cloonan, Olivier J. Becherel, John Finnie, Jeffrey R. Skaar, Carl R. Walkley, Tej K. Pandita, Maga Rowicka, Krzysztof Ginalski, Steven W. Lane, Kum Kum Khanna
Institutions: QIMR Berghofer Medical Research Institute, The University of Queensland, University of Warsaw, The University of Texas Medical Branch at Galveston, Houston Methodist, Houston Methodist Research Institute, Griffith University, Science for Life Laboratory, Karolinska Institutet, South Australia Pathology, The University of Adelaide, New York University, The University of Melbourne, St Vincent's Hospital Melbourne, St Vincents Institute of Medical Research, Royal Brisbane and Women's Hospital
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Role of Heterochromatin protein 1 Beta in Genome Maintenance and Oncogenesis, Chromatin modifying factors control radiation response and genomic stability, Decoding Genome Instability by Combining Accurate Mapping and Predictive Modeling, Tumor-cell-specific targets for combined hyperthermia and radiation effects
OpenAlex ID: W2592973683