Transverse relaxation time constants of the five major metabolites in human brain measured in vivo using LASER and PRESS at 3 T
Year: 2017
Type: article
Abstract: Purpose The goal of this study was to measure and compare the apparent transverse relaxation time constants (T2) of five intracellular metabolites using localization by adiabatic selective refocusing (LASER) and point‐resolved spectroscopy (PRESS) sequences in the human brain at 3 T. Methods Five healthy subjects were studied at 3 T. 1H spectra from the prefrontal cortex were acquired at six different echo times using LASER and PRESS sequences. Postprocessed data were analyzed with LCModel, and the resulting amplitudes were fitted using a mono‐exponential decay function to determine the T2 of metabolites. Results Twenty‐one percent higher apparent T2 values for the singlet resonances of N‐acetyl aspartate, total creatine, and total choline were measured with LASER as compared with PRESS, whereas comparable apparent T2 values were measured for strongly coupled metabolites, glutamate, and myo‐inositol, with both sequences. Conclusions Reliable T2 measurements were obtained with both sequences for the five major intracellular metabolites. The LASER sequence appears to be more efficient in suppressing the diffusion component for singlets (having nonexchangeable protons) compared to J‐coupled metabolites. Magn Reson Med 79:1260–1265, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Source: Magnetic Resonance in Medicine
DOI: 10.1002/mrm.26826
Institution: University of Minnesota
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2734848637