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Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination?

Year: 2017

Type: preprint

Abstract: Immune enhancement of dengue disease continues to be a concern for those with incomplete immunity in endemic areas.Advanced testing and follow-up of a newly available live attenuated dengue vaccine has recently shown the ability of vaccination to predispose some recipients for a severe outcome on subsequent infection.To improve safety, recommendations have been made to restrict use of the vaccine to those who are likely to have had prior exposure to dengue virus (DENV).Researchers continue to investigate dengue immunity and seek evidence that dengue vaccines can be safely administered to all populations needing protection. GREAT DEBATESWhat are the most interesting topics likely to come up over dinner or drinks with your colleagues?Or, more importantly, what are the topics that don't come up because they are a little too controversial?In Immune Memory and Vaccines: Great Debates, Editors Rafi Ahmed and Shane Crotty have put together a collection of articles on such questions, written by thought leaders in these fields, with the freedom to talk about the issues as they see fit.This short, innovative format aims to bring a fresh perspective by encouraging authors to be opinionated, focus on what is most interesting and current, and avoid restating introductory material covered in many other reviews.The Editors posed 13 interesting questions critical for our understanding of vaccines and immune memory to a broad group of experts in the field.In each case, several different perspectives are provided.Note that while each author knew that there were additional scientists addressing the same question, they did not know who these authors were, which ensured the independence of the opinions and perspectives expressed in each article.Our hope is that readers enjoy these articles and that they trigger many more conversations on these important topics.

Source: Cold Spring Harbor Perspectives in Biology

DOI: 10.1101/cshperspect.a028811

Authors: Stephen S. Whitehead, Kanta Subbarao

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: Mosquito-borne diseases and control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases