Beta-blocker Use and Morbidity from Chronic Lung Disease in Patients Undertaking Pulmonary Rehabilitation
Year: 2014
Type: dissertation
Study design: Observational Study
Abstract: Cardiovascular diseases are common in patients with chronic lung diseases. Beta-blockers reduce their morbidity, but are underutilized because of concerns over pulmonary side effects. In this retrospective cohort study, we evaluated the association of beta-blocker use with survival in elderly patients enrolled in pulmonary rehabilitation between 1996-2008. Patient characteristics were abstracted from hospital charts and linked to administrative health databases. Primary outcome was time to death or first hospitalization. Matching on propensity score was used to account for potential confounding. No significant increase was seen in the hazard of death or hospitalization in beta-blocker users. In patients with obstructive lung disease, survival was non-significantly longer among beta-blocker users. Residual imbalance in important confounders remained despite repeated refinement of the propensity-score.Survival to death or hospitalization was not significantly associated with beta-blocker use. Beta-blockers should not be withheld from patients with lung disease who have clinical indications for them.
Source: TSpace (University of Toronto)
Author: Gabriel Robert Varadi
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2735398381