Diagnostic Value of Gadoxetic Acid-Enhanced MR Imaging to Distinguish HCA and Its Subtype from FNH: A Systematic Review
Year: 2017
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: Objective: The purpose of this study was to systematically review the diagnostic performance of gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-DTPA-MRI) for differentiation of hepatocellular adenoma (HCA) and focal nodular hyperplasia (FNH), as well as HCA classification by using the low signal intensity (SI) in the hepatobiliary phase (HBP).Methods: A systematic process was used to review all published data in MEDLINE database about Gd-EOB-DTPA-MRI applied to differentiation of HCA and FNH, and classification of HCA by using low SI in the HBP.The pooled sensitivity and specificity were calculated to assess the diagnostic value of low SI in the HBP.Results: A review of 45 articles identified 10 eligible studies with a total of 288 HCA lesions.The pooled proportion of low SI in the HBP of HCA were 91% (95% CI: 0.81-0.97).In specific, the subtypes of HCA were 75% (95% CI: 0.64-0.85)for I-HCA, 100% (95% CI: 0.95-1.00)for H-HCA, 92% (95% CI: 0.70-1.00)for U-HCA, and 59% (95% CI: 0.00-1.00)for b-HCA, respectively.The pooled specificity and sensitivity of low SI in the HBP for distinguishing FNH from HCA were 95% (95% CI: 0.92-0.98)and 92% (95% CI: 0.87-0.96),respectively.Conclusion: Low SI in the HBP of Gd-EOB-DTPA-MRI is associated with higher accuracy for distinguishing HCA from FNH.However, the diagnostic accuracy may be overvalued, especially for the diagnosis of subtypes of b-HCA and I-HCA.Therefore, the risk factors and conventional imaging findings should be take into account simultaneously.
DOI: 10.7150/ijms.17865
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,337
Award: G3838494142
OpenAlex ID: W2735477616