Work

Stem cell-released oncolytic herpes simplex virus has therapeutic efficacy in brain metastatic melanomas

Year: 2017

Type: article

Abstract: Significance This study provides an insight into stem cell-based oncolytic virus therapies for advanced melanoma tumors that have metastasized into the brain by developing clinically relevant mouse tumor models and testing the fate and efficacy of oncolytic herpes simplex virus-armed mesenchymal stem cells in such models. This study therefore overcomes the hurdles of systemic delivery of oncolytic viruses and provides a clinically applicable therapeutic platform to target melanoma brain metastasis.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1700363114

Authors: Wanlu Du, Ivan Seah, Oumaima Bougazzoul, GiHun Choi, Katrina Meeth, Marcus W. Bosenberg, Hiroaki Wakimoto, David Fisher, Khalid Shah

Institutions: Harvard University, Massachusetts General Hospital, Brigham and Women's Hospital, Yale University, Harvard Stem Cell Institute

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Defense, National Institutes of Health, U.S. Army, National Cancer Institute, Congressionally Directed Medical Research Programs

Awards: G1479411374, G3313674220, G4200032263, In vivo imaging of the stem cell loaded oncolytic viruses for cancer therapy, Fate and efficacy of targeted therapies for metastatic tumors, G5801803100, G6030614427, Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment

OpenAlex ID: W2735777622

FWCI: 6.382

Cites: 54

Cited by: 122

Related to: 10