Work

EP-1749: The IROC QA Center's Activities Supporting the NCI's National Clinical Trial Network

Year: 2017

Type: conference-abstract

Abstract: ResultsMesorectal-only CTVs were median 59% smaller than standard CTVs (interquartile range 58-63%, p<0.001).All VMAT and 3D-CRT plans had V95%=100% for the CTVs, while V95% of the PTV was comparable for VMAT and 3D-CRT plans (median 99.4% vs 99.6%).Table 1 summarizes doses to OARs and CI.All OAR doses for mesorectal-only irradiation were significantly reduced with VMAT compared to 3D-CRT; p<0.001 for all metrics.Suggested optimization objectives for OAR for mesorectal-only VMAT were V10Gy<200cm 3 , V18Gy<120cm 3 , and V23Gy<90cm 3 for bowel cavity; V21Gy<15% for bladder; and V12.5Gy<16% for femoral heads. ConclusionVMAT provides dosimetric advantages over 3D-CRT for mesorectal-only target volumes.The recommended OAR optimization objectives allow for clinical implementation of IMRT/VMAT with improved OAR sparing compared to 3D-CRT standard treatment.These objectives will, after independent validation, be used in the multi-centre STAR-TReC trial.

Source: Radiotherapy and Oncology

DOI: 10.1016/s0167-8140(17)32112-6

Authors: D. Followill, Y. Xiao, J. Michalski, M. Rosen, T. FitzGerald, M. Knopp

Institutions: Tehran University of Medical Sciences, University of Kashan, American College of Radiology, Islamic Azad University, Tehran, Islamic Azad University, Science and Research Branch, Tarbiat Modares University, Lincoln Public Library, Sina Hospital

Language: English

Topic: Advanced Radiotherapy Techniques

Subfield: Radiation

Field: Physics and Astronomy

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,770

OpenAlex ID: W2735941212

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