Work

Congenital myotonic dystrophy—an RNA-mediated disease across a developmental continuum

Year: 2017

Type: preprint

Abstract: Thomas and colleagues (pp. 1122-1133) demonstrate severe dysregulation of developmentally regulated alternative splicing and polyadenylation in congenital myotonic dystrophy (CDM). In doing so, they also highlight the importance of these post-transcriptional processes during normal fetal muscle development. Finally, they generate and characterize a mouse model of CDM that lacks all three Muscleblind-like proteins.

Source: Genes & Development

DOI: 10.1101/gad.302893.117

Authors: Sujatha Jagannathan, Robert K. Bradley

Institution: Fred Hutch Cancer Center

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Ellison Medical Foundation, FSH Society, National Institutes of Health, National Institute of Neurological Disorders and Stroke