Large-scale genomic analyses link reproductive ageing to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
Year: 2020
Type: article
Study design: Observational Study
Abstract: John Perry and colleagues report the results of a large genome-wide association study meta-analysis to identify variants influencing age at natural menopause. They identify 54 independent signals and find enrichment near genes involved in delayed puberty and DNA damage response.
DOI: 10.17615/kjjy-yd65
Authors: Day, Felix R, McArdle, Patrick F, Johnson, Andrew D, Lunetta, Kathryn L, Yao, Jie, Keller, Margaux F, Huffman, Jennifer E, Teumer, Alexander, Thompson, Deborah J, Finucane, Hilary K, Rose, Lynda M, Nutile, Teresa, Franke, Lude L, Vuckovic, Dragana, He, Chunyan, Bulik-Sullivan, Brendan, Porcu, Eleonora, Franceschini, Nora, Zhao, Wei, Chasman, Daniel I, Pervjakova, Natalia, Altmaier, Elisabeth, Stolk, Lisette, Elks, Cathy E, Sulem, Patrick, Ruth, Katherine S, Robino, Antonietta, Smith, Jennifer A, Esko, Tõnu, Brody, Jennifer A, Schick, Ursula M, Traglia, Michela
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2736220940