Humanized Mouse Models for Human Immunodeficiency Virus Infection
Year: 2017
Type: review
Abstract: Human immunodeficiency virus (HIV) remains a significant source of morbidity and mortality worldwide. No effective vaccine is available to prevent HIV transmission, and although antiretroviral therapy can prevent disease progression, it does not cure HIV infection. Substantial effort is therefore currently directed toward basic research on HIV pathogenesis and persistence and developing methods to stop the spread of the HIV epidemic and cure those individuals already infected with HIV. Humanized mice are versatile tools for the study of HIV and its interaction with the human immune system. These models generally consist of immunodeficient mice transplanted with human cells or reconstituted with a near-complete human immune system. Here, we describe the major humanized mouse models currently in use, and some recent advances that have been made in HIV research/therapeutics using these models.
Source: Annual Review of Virology
Authors: Matthew D. Marsden, Jerome A. Zack
Institution: University of California, Los Angeles
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: Centers of Excellence for Influenza Research and Surveillance, Novel method for evaluating HIV latency and persistence in vivo, G3121688723, HIV Latency Reversal Through Novel, Potent PKC Modulators, Targeting HIV Reservoirs in vitro and in vivo, UCLA Center for AIDS Research (CFAR), HIV latency reversal through novel, potent PKC modulators
OpenAlex ID: W2736531288